Given the recent debunking of the serotonin theory of depression, Dr. Weiner explores glutamate’s role in depression and neuroplasticity, exploring how glutamate's complex signaling mechanisms contribute to mood regulation and mental health, offering new perspectives for effective treatments.

Dr. Weiner explores a recently published secondary analysis of a trial that compared ketamine to electroconvulsive therapy (ECT) for treatment-resistant depression, finding that ECT and ketam!ne both effective long-term, with moderate to severe depression patients having faster improvement with ketamine, and very severe depression responding faster to ECT.