KETAMINE
Transformative medicine

Ketamine is currently the only legal psychedelic medicine in the nation. Research has shown using ketamine under supported supervision may have profound therapeutic capabilities.

Ketamine is a transformative medicine. Dr. Weiner gets to the root cause of one’s suffering using a biopsychosocial model to heal the whole person. Ketamine may act as a catalyst to change. Through proper integration including cultivating health, ketamine assisted psychotherapy can have longer lasting benefits.   Ketamine is an anesthetic that was approved by the FDA in 1970 and quickly became one of the most widely used anesthetics in the world. Ketamine’s unique mechanism of action means that it works differently from the typical medications used for these conditions, offering patients new hope when all others have failed them. Ketamine dampens our ego or personal narrative, allows us to unlearn, depattern and reinforce positive thoughts attitudes and behaviors while promoting new neural connections. Using a therapeutic alliance, Dr. Weiner and the therapist use this mind manifesting or meaning making medicine heal past trauma using evidence based transformative medicine.

Ketamine is FDA approved.  Cleveland Clinic called It a “Top 10 medical breakthrough” for treatment resistant depression. 

The treatment is very simple; we give you one to two intramuscular injections or an oral lozenge over a 60- 90 min period, and you lay back and relax with headphones and eye shades on. Unlike other psychedelics which makes you go into your story, Ketamine takes you away from your personal narrative. The science is that in the hours after the treatment, the Ketamine metabolizes and it builds new neural pathways in the brain around trauma, pain and depression.  

The protocol established by Yale University for treatment resistant depression is to receive weekly treatments for 6 consecutive weeks. 

We recommend that you do one treatment, at a low dose and we assess your outcome together and then can schedule the additional treatments based on your goals.  Some people prefer to be alone during his/her journey with no distractions; others feel better from low doses of ketamine with psychotherapy during his/her sessions. Others based on multiple factors such as past psychedelic experience, diagnosis, culture and past trauma improve from the dissociation and profound mystical experience.  

Frequently Asked Questions

About Ketamine-Assisted Psychotherapy (KAP) Treatments

Ketamine therapy can relieve various types of depression, suicidal thinking, post-traumatic stress disorder (PTSD), anxiety, obsessive-compulsive disorder (OCD), other mood disorders, and chronic pain conditions.

Ketamine is actually the number one anesthetic that oral surgeons use on children because it’s very safe and doesn’t affect their breathing. Yale University figured out that if you give someone a low dose of Ketamine it can break depression, anxiety, and even help with addiction.  It’s very unique and unlike antidepressants which work on the serotonergic pathways ketamine has been shown to activate the brain in a way that gets to the root of the trauma.  

The protocol for treatment resistant depression is to receive weekly treatments for 6 consecutive weeks. Some benefit from booster sessions a few months after.   The idea with Ketamine is that you’re building up more neural pathways in your brain to offset the trauma that may be there because of your personal trauma, life experiences, genetics. Ketamine can help you depattern and adapt and be less affected by triggers allowing you to create a healthier pathway down the ski slope instead of assuming your usual ride. 

We do not prescribe oral ketamine for use at home. Using ketamine in a medical setting through IM injection or oral route with guidance and psychotherapy are the best options. There is no opportunity for addiction if the patient can not take home ketamine for repetitive use. The idea is that a series of sessions using ketamine may have long lasting effects so that we can decrease pharmaceutical use and addiction and feel well. We also do not recommend the intranasal route. 

No, Ketamine is not a hallucinogenic it’s a dissociative, which means it disassociates your left and right brain and allows them to communicate freely without your ego being involved. Other Hallucinogens like LSD or mushrooms can create hallucinations, most patients described Ketamine as being one of the most peaceful experiences of their whole life.

Quite the opposite. Most people report it to be very calming and overall peaceful experience.  We typically begin with a starter dose which is based on your body weight and previous experience so you are getting a small dose, but we want you to in that experience see that this is unlike any other treatment you’ve ever had and that it’s getting to the root of your trauma or depression, allowing you look at it from a third party perspective, most people find that experience very healing, and afterwards they report that the thing that was bothering them no longer has the same electric charge to it.

Ketamine is extremely safe, that’s why they use it on children for surgery, the only negative side effect reported is nausea, so we give you an anti-nausea medication before your treatment… the last thing we want is for you to walk out feeling really good but being sick to your stomach.  

We recommend you continue your medication, as you can imagine most people who are suffering with depression or anxiety or pain have tried a number of different medications, and are usually on a few when they come in for their first treatment. We have noticed that overtime people who do the ketamine treatment tend to need less medication.

We charge $300 for a ketamine treatment, with the protocol being to receive weekly treatments for 6 consecutive weeks. Since it’s works so quickly and effectively most people find it to be very cost effective.  

Unfortunately, it is not covered by insurance. We hope this insurance coverage changes in the future. We want Ketamine to be an option for those suffering and unfortunately most who try ketamine have already tried and failed other medications. 

Ketamine is an NMDA receptor antagonist and an AMPA receptor stimulator. AMPA stimulation is necessary for increasing brain derived neurotrophic factor (BDNF) which in turn stimulates the formation of new receptors and synapses. This process is critical for making connections between neurons and is often severely compromised among those suffering from PTSD, depression, and mood disorders.

Clinical Trials

by Dr. Michelle Weiner, DO, MPH

STAR D

According to STAR D trial, 1/3 will never respond to antidepressants. Moving from a daily dosed medication to a few sessions of ketamine therapy is a paradigm shift in medicine.

Cognitive Behavior Therapy May Sustain Antidepressant Effects of Intravenous Ketamine in Treatment-Resistant Depression

Psychotherapy and integration with ketamine will enhance the outcome.

The New Frontier: Psychedelic Therapy

by Dr. Michelle Weiner DO, MPH

A Psychedelic Renaissance is underway causing a paradigm shift where science and spirituality meet. Psychedelics literally means “mind manifesting.” Cannabis is now legal for medical purposes in 33 states. Entheogens are psychoactive substances in a spiritual context such as psilocybin (magic mushrooms), MDMA (ecstasy), mescaline derived from peyote (Ayahuasca), ibogaine, mescaline, DMT. They are classified as Schedule 1 drugs yet the government is greenlighting research. Rapid changes to embracing psychedelic substances by mainstream medicine is happening.  With research not just anecdotes, we are understanding that altered states of consciousness can lead to profound insight, psychospiritual exploration, personal development, and emotional release.

(KAP) Ketamine-Assisted 
Psychotherapy

This helps one open his/her mind to new perspectives, improve motivation, become more engaged and focused in therapy, feel comfortable sharing past traumas, and change repetitive maladaptive behaviors.

Dr. Michelle Weiner collaborates with Mindful Psychedelics and Cannected Wellness.

"The psychedelic effects may occasion mystical experiences, a sense of awe, and changes in the way intrapsychic conducts and possible solutions to them are perceived. Ego defenses are altered and with the expertise of a skilled psychotherapist the experience may yielded insights and improvement in maladaptive patterns of behavior."
Raquel Bennett
Ethical Guidelines for Ketamine Clinicians

Dr. Michelle Weiner, DO, MPH

Co-Founder of Mr. Psychedelic Law

Dr. Weiner is the Vice President of Mr Psychedelic Law, a not-for-profit with the mission of responsible legal reform of psilocybin mushrooms in Florida.

Education & ARTiCLES

Time to Relapse After a Single Administration of Intravenous Ketamine Augmentation in Unipolar Treatment-resistant Depression

Of the 60 randomized participants who received a single ketamine (0.1, 0.5, or 1.0 mg/kg) infusion, 19 (34%) met criteria for remission and 27 (48%) for response, on day 3 post-infusion.

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Cognitive Behavior Therapy May Sustain Antidepressant Effects of Intravenous Ketamine in Treatment-Resistant Depression

CBT may sustain the antidepressant effects of ketamine in treatment-resistant depression. Well-powered randomized controlled trials are warranted to further investigate this treatment combination as a way to sustain ketamine's antidepressant effects.

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A Randomized Controlled Trial of Repeated Ketamine Administration for Chronic Posttraumatic Stress Disorder

This randomized controlled trial provides the first evidence of efficacy of repeated ketamine infusions in reducing symptom severity in individuals with chronic PTSD. Further studies are warranted to understand ketamine’s full potential as a treatment for chronic PTSD.

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Ketamine’s antidepressive effects tied to opioid system in brain by Stanford Medicine

Ketamine’s antidepressive effects require activation of opioid receptors in the brain, a new Stanford study shows. The surprising finding may alter how new antidepressants are developed and administered in order to mitigate the risk of opioid dependence.

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ketamine

How New Ketamine Drug Helps with Depression

Yale psychiatrists, pioneers of ketamine research, shed light on new FDA approval. On March 5, the Food and Drug Administration (FDA) approved the first truly new medication for major depression in decades. The drug is a nasal spray called esketamine, derived from ketamine—an anesthetic that has made waves for its surprising antidepressant effect.

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ketamine Broward County

Evidence based practices for Ketamine

Here are some key points from this comprehensive review: Ketamine Assisted Psychotherapy (KAP) utilizes a dosage escalation strategy to achieve different levels of trance increasing to full out-of-body experiences. We begin with the sublingual induction of the trance state to find an individual “sweet spot” with respect to dosage that can be replicated at home under supervision and used in future in office sessions to aid in psychotherapy.

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MDMA

Five Things to Know About MDMA-Assisted Psychotherapy for PTSD // Mount Sinai

MDMA, the psychoactive drug sometimes known as ecstasy, is poised to become a powerful tool in the treatment of PTSD. In 2017, the U.S. Food and Drug Administration (FDA) designated MDMA-assisted psychotherapy as a breakthrough therapy. Although MDMA itself is not officially legal or approved for clinical use, phase III trials are underway, and expanded access status was granted in January in the United States and Israel. The results of preliminary clinical studies are extremely promising, and the FDA could approve MDMA-assisted psychotherapy for PTSD as early as 2022.

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brain ketamine

Emotional Adjustment: The Modulatory Influence of Psilocybin on the Amygdala

Recent research suggests that psilocybin causes changes in amygdala activity opposite to those seen in conventional antidepressant treatment.

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Ketamine Assisted Psychotherapy (KAP): Patient Demographics, Clinical Data and Outcomes in Three Large Practices Administering Ketamine with Psychotherapy

Ketamine Assisted Psychotherapy is a new and unique methodology with a rapidly growing group of practitioners participating in its development and practice. We have presented a view of its current status combining data from three different related centers, with attendant outcomes with correlations. Psychedelic experience is an inherent, valued, and well-tolerated part of our methodology. Our data support the efficacy of KAP for a wide variety of psychiatric diagnoses and human difficulties, significantly diminishing depression, anxiety, and PTSD and increasing well-being.

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USA: The Psychedelic Movement Spreads its Spores to the Sunshine State

As dozens of groups spread across the country with the purpose of decriminalizing entheogenic plants and fungi, a new group has emerged in Florida, Mr. Psychedelic Law, stacked with doctors, lawyers, spiritual leaders, lobbyists, therapists, and other industry-leading professionals. As explained on their website, the mission of Mr. Psychedelic Law is to use medical and spiritual research to drive responsible legal reform in Florida for psilocybin mushrooms and other entheogenic plants and fungi.

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Untitled design-2

Paradigm Shift

A Psychedelic Renaissance is underway causing a paradigm shift where science and spirituality meet. Psychedelics literally means “mind manifesting.” Cannabis is now legal for medical purposes in 33 states. Entheogens are psychoactive substances in a spiritual context such as psilocybin (magic mushrooms), MDMA (ecstasy), mescaline derived from peyote (Ayahuasca), ibogaine, mescaline, DMT. They are classified as Schedule 1 drugs yet the government is greenlighting research. Rapid changes to embracing psychedelic substances by mainstream medicine is happening. With research not just anecdotes, we are understanding that altered states of consciousness can lead to profound insight, psychospiritual exploration, personal development, and emotional release.

Read More