Dr. Weiner explores a recently published secondary analysis of a trial that compared ketamine to electroconvulsive therapy (ECT) for treatment-resistant depression, finding that ECT and ketam!ne both effective long-term, with moderate to severe depression patients having faster improvement with ketamine, and very severe depression responding faster to ECT.

Dr. Weiner reviews a recently published deep dive into ketamine's use as a rapid antidepressant, exploring its potential and pitfalls and highlighting therapeutic effects, ethical concerns, and safety issues in treatment-resistant depression.

New (May 2024) research unveils the mechanisms behind ketamine's ability to induce altered brain oscillations, offering profound insights into its therapeutic potential and the nature of consciousness itself.

A recent study explores the effect of a “relational dose” of ketamine combined with Imago relationship therapy for couples; quantitative data showed significant improvements in relationship satisfaction scores post-treatment, with benefits persisting for up to 15 months.

A recent study offers a fresh perspective on pain by applying the lens of complexity science to chronic pain. We review the study's key points and discuss how psychedelic therapies may offer promising solutions.

A recent study examined the role of the therapeutic alliance between patients and intervention facilitators in PAT for MDD. The study found that a stronger therapeutic alliance was associated with more positive outcomes for patients.

A recent study found that ketamine metabolite (2R,6R)-hydroxynorketamine effectively reduces anxiety-like behaviors associated with morphine withdrawal in mice by modulating neuronal excitability and potassium channel activity in the brain.

A single low dose of esketamine administered right after childbirth shows promise for postpartum depression, showing it could be a viable treatment option for new mothers showing signs of prenatal depression.

Ketamine shows better faster relief with fewer adverse events.

The retrospective study analyzed 68 treatment sessions involving 41 patients aged 5-21 years, predominantly girls with chronic migraine without aura. Patients were administered a median dose of 0.25 mg/kg/hr of IV ketamine over a median duration of 3 days.